Anna Wintour is officially stepping down as editor-in-chief of Vogue after an iconic 37-year run that reshaped the fashion world and defined magazine culture for a generation.

As confirmed by The Daily Front Row and Business of Fashion, Wintour, 75, announced her departure during a staff meeting on the morning of Wednesday, June 25. Her exit marks the end of an era at Vogue, where she has been at the helm since 1988.

While Wintour is stepping down from the U.S. edition of Vogue, she will remain actively involved at Condé Nast, continuing her role as global chief content officer and global editorial director for Vogue worldwide. In that capacity, she will continue to oversee the brand’s international editions as well as other major titles under the Condé Nast umbrella, including Vanity Fair, GQ, and Architectural Digest.

Wintour first joined Vogue in 1983 as creative director before briefly taking charge of British Vogue. She returned to lead the U.S. edition in 1988, succeeding Grace Mirabella. Her debut cover, featuring model Michaela Bercu wearing a $10,000 Christian Lacroix sweater paired with $50 jeans, broke with convention and signaled a new, modern direction for the magazine.

“It was so unlike the studied and elegant close-ups that were typical of Vogue’s covers back then,” Wintour recalled in a 2012 interview. “This one broke all the rules… I had just looked at that picture and sensed the winds of change.”

During her nearly four-decade tenure, Wintour transformed Vogue into a global fashion authority and cultural tastemaker, known for its trendsetting covers, powerful influence, and connection to the biggest names in fashion, entertainment, and politics.

A successor for the editor-in-chief role has not yet been named. Wintour’s departure from the role signals a major shift for Vogue and the fashion media landscape as a whole.